Acamprosate: A Practical Guide to Preventing Alcohol Relapse
Looking for a clear, no-nonsense explanation of acamprosate? You’re in the right place. Acamprosate (brand name Campral) is a prescription drug used to help people stay abstinent after they stop drinking. It works best when paired with counseling or a support program, not as a solo fix.
How acamprosate works and who it's for
Acamprosate helps calm brain systems that get thrown off by long-term alcohol use. It doesn’t make you sleepy or cause dependence like some other meds. Instead, it helps reduce cravings and the drive to drink by balancing certain neurotransmitters (GABA and glutamate). Doctors usually prescribe it for people who are already detoxed and want to avoid relapse.
It’s not for everyone. Don’t take acamprosate if you have severe kidney problems. Tell your doctor about pregnancy, breastfeeding, or if you’re allergic to its ingredients. In many countries it’s available only with a prescription.
Practical dosing and what to expect
Typical adult dose: 666 mg three times a day (often given as two 333 mg tablets, three times daily). That’s about 1998 mg per day. Take doses around the same times each day to keep levels steady. You can take it with or without food—water helps if tablets feel dry going down.
How fast will it work? Don’t expect overnight results. Some people notice less craving within a week or two; for others it can take longer. Studies show better results when medication is combined with therapy, peer support, or outpatient programs.
If you miss a dose, skip it and take the next one at the usual time. Don’t double up. For people with moderate kidney impairment, doctors may lower the dose. In severe renal failure, acamprosate is generally avoided.
Side effects are usually mild. The most common is diarrhea. Others include nausea, anxiety, sleep trouble, and skin itchiness. Serious reactions are rare but get medical help for signs of severe allergy or sudden kidney issues.
Drug interactions are limited because acamprosate is not heavily metabolized by the liver. It’s often used together with naltrexone or behavioral therapy. Still, tell your provider about all medicines and supplements you take.
Storage and safety: keep tablets in their original container, at room temperature, and out of reach of children. If you think you or someone else overdosed, seek emergency care—treatment is supportive.
Bottom line: acamprosate can be a useful tool to reduce relapse risk when used correctly and combined with counseling. Talk to your doctor about kidney checks, the right dose for you, and setting up a support plan that fits your life.
